Methotrexate and Grapefruit?

By Kymii Latest Activity October 14, 2010 at 12:07 pm Views 16,528 Replies 5 Likes 5


A friend sent me information that you should not eat grapefruits while taking methotrexate as it can change/metabolize the medication which can increase the dosage that we are receiving, causing toxic effects. Does anyone have any information on this?

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Replies (5 replies)

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  • aurorab
    aurorab October 7, 2012 at 2:58 am   

    I have heard of this. I'm also in a clinical study so I can't have it anyway. It reacts 2 several meds.

  • Mangosteen
    Mangosteen October 2, 2012 at 8:18 am   

    I have heard about grapefruit reacting to certain meds but was not aware methotrexate was one of them. Thanks for the useful info. I very rarely eat grapefruit but I do like to eat it sometimes

  • egbrown
    egbrown January 28, 2011 at 11:33 am   

    Grapefruit juice is not recommended while taking prescription medication of any kind. I juice two every every morning but I take no drugs. You really don't want my opinion about drugs.

  • Lana
    Lana October 14, 2010 at 12:46 pm   

    Yes, I have heard this too. If anything, it will only cause an upset stomach. As a matter a fact, it does not apply to Methotrexate alone. With some medications, grapefruit may hinder absorption of the drug into the blood stream. Here is a link to some information. I think the key is not to take it with your meds. So I would suggest waiting an hour before you drink it after taking your meds or an hour before taking them.

  • RhyB
    RhyB October 25, 2010 at 3:44 pm   

    Grapefruit is counter-indicated with many drugs today. it can cause anything from an upset stomach to liver failure. If you like grapefruit you should ask your pharmacist.

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